Contacts:
En-Te Hwu, etehw@dtu.dk, Phone: 53815266, Office: 345C-R115
Location*: B347/R081
*Location should be the meeting place for the project
Task:
Hands-on Atomic Force Microscope operation for skin cell nanotexture measurement, calibration, image post processing and data analysis.
Description:
You are going to learn the theory, operation and calibration of an important nano-imaging tool: Atomic Force Microscope (AFM). Furthermore, prepare human skin corneocyte cell sample by a tape stripping method. Use a simplified AFM scanning with a constant height contact mode for measuring topographic difference of the skin corneocyte cell sample surface in room temperature.
By analysing the skin nanotexture data, circular nanotexture density on the skin can be quantified into a dermal texture index (DTI). Increased DTI links to several subclinical phase skin diseases such as atopic dermatitis (AD), psoriasis, actinic keratosis (AK) and irritant contact dermatitis (ICD).
